huji Institute of Biochemistry, Food Science and Nutrition

Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem

Ido Goldstein, Ph.D.

 

Office Address:
Institute of Biochemistry, Food Science and Nutrition,
Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem,
P.O.Box 12, Rehovot 76100, ISRAEL
Fribourg Bldg. ground floor, Room 15.

Tel: +972–(0)8–9489626

Email Address: ido.goldstein@mail.huji.ac.il

 

Lab of Nutrigenomics, Liver Biology and Gene Expression

scheme

The liver is central to various systemic functions. The liver is responsible for generating lipid and carbohydrate reservoirs following feeding and production of alternative fuels during fasting. It produces and secretes bile acids as well as acute phase reactants, regulates iron and cholesterol homeostasis and detoxifies drugs. A large body of data is available to show that many of these functions are regulated by dynamic hepatic gene expression patterns.

Our lab uses genomic, metabolic and molecular biology approaches to investigate how gene expression is regulated in the liver. We study the gene regulatory networks that mediate the liver’s response to nutritional status (e.g. fasting and different diet regimens) with an emphasis on transcriptional and chromatin regulation. The transcriptional networks regulating systemic metabolism in response to diet are dysregulated during diabetes and contribute to its pathogenesis. Therefore, modulation of these networks has a therapeutic potential.

pmh
Primary mouse hepatocytes

K&E Design
© The Hebrew University of Jerusalem