huji Institute of Biochemistry, Food Science and Nutrition

Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem

Prof. Oren Froy

Prof. Oren Froy

List of Publications


  1. Zilberberg N, Froy O, Loret E, Cestele S, Arad D, Gordon D, Gurevitz M. (1997). Identification of structural elements of a scorpion a–neurotoxin important for receptor site recognition. J Biol Chem, 272:14810–14816.
  2. Gershburg E, Stockholm D, Froy O, Rashi S, Gurevitz M, Chejanovsky N. (1998). Baculovirus mediated expression of a scorpion depressant toxin improves significantly the insecticidal efficacy achieved with excitatory toxins. FEBS Lett, 422:132–136.
  3. Oren D*, Froy O*, Amit E, Kleinberger–Doron N, Gurevitz M, Shaanan B. (1998). An excitatory scorpion toxin with a distinctive feature: an additional a–helix at the C–terminus and its implications for interaction with insect sodium channels. Structure, 6:1095–1103.
  4. Froy O, Gurevitz M. (1998). Membrane potential modulators – a thread of scarlet from plants to humans. FASEB J, 12:1793–1796.
  5. Gurevitz M, Froy O, Zilberberg N, Turkov M, Strugatsky D, Gershburg E, Lee D, Adams ME, Tugarinov V, Anglister J, Shaanan B, Loret E, Stankiewicz M, Pelhate M, Gordon D, Chejanovsky N. (1998). Sodium channel modifiers from scorpion venom: Structure–activity relationship, mode of action, and application. Toxicon, 36:1671–1682.
  6. Froy O, Sagiv T, Poreh M, Urbach D, Zilberberg N, Gurevitz M. (1999). Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium, and chloride channels. J Mol Evol, 48:187–196.
  7. Froy O, Zilberberg N, Gordon D, Turkov M, Gilles N, Stankiewicz M, Pelhate M, Loret E, Oren D, Shaanan B, Gurevitz M. (1999). The putative bioactive surface of insect–selective scorpion excitatory neurotoxins. J Biol Chem, 274:5769–5776.
  8. Froy O, Zilberberg N, Chejanovsky N, Anglister J, Loret E, Shaanan B, Gordon D, Gurevitz M. (2000). Scorpion neurotoxins: Structure/function relationships and application in agriculture. Pest Manag Sci, 56:472–474.
  9. Gilles N, Krimm I, Bouet F, Froy O, Gurevitz M, Lancelin J–M, Gordon D. (2000). Structural implications on the interaction of scorpion a–like toxins with the sodium channel receptor site inferred from toxin iodination and pH–dependent binding. J Neurochem, 75:1735–1745.
  10. Gurevitz M, Gordon D, Ben–Natan S, Turkov M, Froy O. (2001). Diversification of neurotoxins by C–tail wiggling: a scorpion recipe for survival. FASEB J, 15:1201–1205.
  11. Froy O, Chang DC, Reppert SM. (2002). Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol, 12:147–152.
  12. Froy O, Gotter AL, Casselman AL, Reppert SM. (2003). Illuminating the circadian clock in monarch butterfly migration. Science, 300:1303–1305.
  13. Gordon D, Ilan N, Zilberberg N, Gilles N, Urbach D, Cohen L, Karbat I, Froy O, Gaathon A, Kallen RG, Benveniste M, Gurevitz M. (2003). An ‘Old World’ scorpion b–toxin that recognizes both insect and mammalian sodium channels. Eur J Biochem, 270:2663–2670.
  14. Froy O, Gurevitz M. (2003). New insight on scorpion divergence inferred from comparative analysis of toxin structure, pharmacology, and distribution. Toxicon, 42:549–555.
  15. Froy O, Gurevitz M. (2003). Arthropod and mollusk defensins – evolution by exon–shuffling. Trends Genet, 19:684–687.
  16. Cohen L, Karbat I, Gilles N, Froy O, Angelovici R, Gordon D, Gurevitz M. (2004). Dissection of the functional surface of an anti–insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta–toxins affecting Na+ channels. J Biol Chem, 279:8206–8211.
  17. Karbat I, Frolow F, Froy O, Gilles N, Cohen L, Turkov M, Gordon D, Gurevitz M. (2004). Molecular basis of the high insecticidal potency of scorpion alpha–toxins. J Biol Chem, 279:31679–31686.
  18. Froy O, Gurevitz M. (2004) Arthropod defensins illuminate the divergence of scorpion neurotoxins. J Pept Sci, 10:714–718.
  19. Froy O, Hananel A, Chapnik N, Madar Z. (2005). Differential expression of rat β–defensins. IUBMB Life, 41–43.
  20. Sauman I, Briscoe AD, Zhu H, Shi D, Froy O, Stalleicken J, Yuan Q, Casselman A, Reppert SM. (2005). Connecting the navigational clock to sun compass input in monarch butterfly brain. Neuron, 46:457–467.
  21. Froy O (PI). (2005). Convergent evolution of invertebrate defensins and nematode antibacterial factors. Trends Microbiol, 13:314–319.
  22. Froy O. (2005). Regulation of mammalian defensin expression by TLR–dependent and TLR–independent pathways. Cell Microbiol, 7:1387–1397.
  23. Froy O, Chapnik N, Miskin R. (2005). Mouse intestinal cryptdins exhibit circadian oscillation. FASEB J, 19:1920–1922.
  24. Sherman H, Chapnik N, Froy O. (2006). Albumin and amino acids upregulate the expression of human beta–defensin 1. Mol Immunol, 43: 1617–1623.
  25. Froy O, Levkovich G, Chapnik N. (2006). Immunonutrition enhances the expression of mouse intestinal defensins. Gut, 55:900–901.
  26. Froy O, Chapnik N, Miskin R. (2006). Long–lived alphaMUPA transgenic mice exhibit pronounced circadian rhythms. Am J Physiol Endocrinol Metab, 291:E1017–E1024.
  27. Froy O, Hananel A, Chapnik N, Madar Z. (2006). Differential effect of insulin treatment on decreased levels of beta–defensins and Toll–like receptors in diabetic rats. Mol Immunol, 44:796–802.
  28. Froy O, Chapnik N. (2007). Circadian oscillation of innate immunity components in the mouse gut. Mol Immunol, 44:1954–1960.
  29. Froy O Miskin R. (2007). The interrelations among feeding, biological rhythms, and aging. Prog Neurobiol, 82:142–150.
  30. Froy O. (2007). The relationship between nutrition and circadian rhythms in mammals. Front Neuroendocrinol, 28:61–71.
  31. Chapnik N, Sherman H, Froy O. (2007). A one–tube site–directed mutagenesis method using PCR and primer extension. Anal Biochem, 372:255–257.
  32. Barnea M, Madar Z, Froy O. (2008). Glucose and insulin are needed for optimal defensin expression in human cell lines. Biochem Biophys Res Commun, 367:452–456.
  33. Froy O, Chapnik N, Miskin R. (2008). Relationship between calorie restriction and the biological clock: lessons from long–lived transgenic mice. Rejuvenation Res, 11:467–471.
  34. Sherman H, Froy O. (2008). Expression of human beta–defensin 1 is regulated via c–Myc and the biological clock. Mol Immunol, 45:3163–3167.
  35. Froy O, Chapnik N, Miskin R. (2008). The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding. Neuroscience, 155:1152–1159.
  36. Barnea M, Madar Z, Froy O. (2008). High–fat diet delays and fasting advances the circadian expression of adiponectin signaling components in mouse liver. Endocrinology, 150:161-168.
  37. Sthoeger ZM, Bezalel S, Chapnik N, Asher I, Froy O. (2008). High α–defensin levels in systemic lupus erythematosus patients. Immunology, in press.
  38. Froy O, Chapnik N, Miskin R. (2008). Effect of intermittent fasting on circadian rhythms in mice depends on feeding time. Mech Ageing Dev, in press.
  39. Froy O. (2008). Cytochrome P450 and the biological clock in mammals. Curr Drug Metab, in press.

Chapters in Collections:

  1. Gurevitz M, Zilberberg N, Froy O, Urbach D, Zlotkin E, Hammock BD, Herrmann R, Moskowitz H, Chejanovsky N. (1996). Utilisation of scorpion insecticidal neurotoxins for the design of novel selective biopesticides. In: “Modern Agriculture and the Environment” (Rosen D, Tel-Or E, eds), pp. 81-96, Lancaster, UK: Kluwer Academic Publ.
  2. Gurevitz M, Froy O, Zilberberg N, Shaanan B, Adams ME, Anglister J, Pelhate M, Chejanovsky N, Gordon D. (1999). Sodium channel modulators from scorpion venoms: Structure-activity relationship and application. In: “Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs” (Beadle D, ed). pp. 67-80, Cambridge, UK: Royal Society of Chemistry.
  3. Gurevitz M, Froy O, Zilberberg N, Turkov M, Wilonsky R, Karbat I, Anglister J, Shaanan B, Pelhate M, Adams ME, Gilles N, Gordon D. (2001) Diversification of toxic sites on a conserved protein scaffold: a scorpion recipe for survival. In: “Perspectives in Molecular Tocxinology” (Menez A, ed), pp. 239-253, Wiley and Sons, Chichister, UK.
  4. Froy O (2005). The biological clock, food and nutrition. In: “Food, wellness, and the biological clock” (Froy O and Le Coutre J, eds), pp. 21-26, Nestle Research Center publication, Lausanne, Switzerland.
  5. Froy O (2008). Obesity and the Circadian Clock. In: “Obesity and Cancer Research” (Pauline R. Ramonde and Eva H. Fochas eds.), Nova Science Publishers, Inc., NY, USA.



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