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The Robert H. Smith Faculty of Agriculture, Food and Environment
SCHOOL OF NUTRITIONAL SCIENCES

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Prof Zvi Zadik M.D.

Institute of Biochemistry, Food Science and Nutrition

Prof Zvi Zadik M.D.

My research and teaching activities focus on the metabolism, physiology and mechanism of growth and nutrition, growth promoting medications and nutritional modulation of hormonal system in children and adolescents.

Director, Pediatric Endocrine Unit, Kaplan Medical Center

Institute of Biochemistry, Food Science and Nutrition,
The Robert H. Smith Faculty of Agriculture, Food and Environment
The Hebrew University of Jerusalem.
P.O. Box 12, Rehovot 76100, Israel.
Tel: 972-8-9489020.
E-mail address: zvizadik@012.net.il

Our main research interests are:

  1. Growth patterns of Israeli children. Cumulative data base since 1977
  2. Nutritional effects on growth:
    • Vitamins and trace elements.
    • Interaction of vitamin A and iron.
    • Effect of nutrition on puberty.
  3. Pediatric and maternal nutrition: Interaction of nutrition and growth: in short children and IUGR.
  4. Effect of nutrition on response to growth promoting medications.
  5. Growth hormone clinical trials
  6. Effect of growth, nutrition and physical activity on bone mass accumulation

Selected Publications – from last five years

  1. Zadik Z, Frishberg Y , Drukker A , Blachar Y , Lotan D , Levi S, Reifen R 1998 Excessive dietary protein and suboptimal caloric intake have a negative effect on the growth of children with chronic renal disease before and during growth hormone therapy. Metabolism. 47:264-268.
  2. Zadik Z , Amer R, Dolfin Z,, Arnon S , Cohen D , Mogilner B , Reifen Rc 1999 Urinary free cortisol (UFC) values in newborns under stress. J Pediatr Endocrinol Metab. 12:543-547.
  3. Hochberg Z , Zadik Z 1999 Final height in young women with Turner syndrome after GH therapy: an open controlled study. Eur J Endocrinol. 141:218-24.
  4. Zung A , Phillip M, Chalew SA, Palese T, Kowarski AA, Zadik Z 1999 Testosterone effect on growth and growth mediators of the GH-IGF-I axis in the liver and epiphyseal growth plate of juvenile rats. J Mol Endocrinol. 23:209-221
  5. Zadik Z, Chalew SA 1999 Short stature. Isr Med Assoc J. 1:206-208.
  6. Zadik Z, Wittenberg I, Segal N, Altman Y, Zung A, Gross V , Reifen R 2001 Interrelationship between insulin, leptin and growth hormone in growth hormone-treated children. Int J Obes Relat Metab Disord. 25:538-542.
  7. Zung A, Reifen R, Kerem Z, Zadik Z 2001 Phytoestrogens: the pediatric perspective. J Pediatr Gastroenterol Nutr. 33:112-118.
  8. Zung A, Zadik Z 2002. Continuous subcutaneous glucose monitoring in children with type 1 diabetes. Pediatrics. 109:347.
  9. Hochberg Z, Bereket A, Davenport M, Delemarre-Van de Waal HA, De Schepper J, Levine MA, Shaw N, Schoenau E, van Coeverden SC, Weisman Y, Zadik Z, 2002 European Society for Paediatric Endocrinology (ESPE) Bone Club. Consensus development for the supplementation of vitamin D in childhood and adolescence. Horm Res. 58:39-51
  10. Aimaretti G, Baffoni C ,Di Vito L, Grottoli S , Gaia D, Gasco V, Giordano R, Zadik Z, Camanni F , Ghigo E, Arvat E 2003 Hypopituitaric patients with corticotropin insufficiency show marked impairment of the cortisol response to ACTH (1-24) independently of the duration of the disease. J Endocrinol Invest. 26:49-55.
  11. Blank S, Zadik Z , Katz I, Mahazri Y ,Toker I, Barak I. 2002 The emergence and treatment of anorexia and bulimia nervosa. A comprehensive and practical model. Int J Adolesc Med Health. 14:257-260.
  12. Zadik Z. 2003 Physiological but not pharmacological growth hormone tests predict adult height. Clin Endocrinol (Oxf). 59:25-26.
  13. Zadik Z, Price D, Diamond G. 2003 Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int. 14:857-862
  14. Zung A, Zadik Z. 2003 Acarbose treatment of infant dumping syndrome: extensive study of glucose dynamics and long-term follow-up. J Pediatr Endocrinol Metab. 16 :907-915.
  15. Zadik Z, Borondukov E, Zung A, Reifen R. 2003 Adult height and weight of breast-fed and bottle-fed Israeli infants. J Pediatr Gastroenterol Nutr 37:462-467.
  16. Zadik Z. 2003 Maternal nutrition, fetal weight, body composition and disease in later life. J Endocrinol Invest. 26:941-945.
  17. Schoenau E, Saggese G, Peter F, Baroncelli GI, Shaw NJ, Crabtree NJ, Zadik Z, Neu CM, Noordam C, Radetti G, Hochberg Z. 2004 From Bone Biology to Bone Analysis. Horm Res. 2004; 61:257-69.
  18. Zadik Z 2004 Vitamin A and Iron are as effective as hormonal therapy in delayed puberty Clin Endocrinol (Oxf). 60:682-7.
  19. Zadik Z 2004 Small for gestational age: Towards 2004 J Endocrinol Invest. 26:1143-50.
  20. Zadik Z, Zung A, Reifen R. (2005) Longitudinal monitoring of bone development measured by quantitative multi-site ultrasound of bones in patients with crohns’ disease. J. Clin Gastroenterol 39:120-123
  21. Zung A, Glaser B , Nimri R , Zadik Z : (2004) Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2. J Clin Endocrinol Metab. 89:5504-7.
  22. Zung A , Yaron A , Altman Y , Zadik Z : (2005){beta}-Adrenergic Hyperresponsiveness in Compensated Hypothyroidism Associated with Down Syndrome. Pediatr Res. 58:66-70
  23. Zadik Z, Sinai T , Zung A , Reifen R . (2005) Effect of nutrition on growth in short stature before and during growth hormone therapy Pediatrics 116:68-72
  24. Zadik Z, Zung A, Reifen R. Longitudinal monitoring of bone development measured by quantitative multi-site ultrasound of bones in patients with crohns’ disease. J. Clin Gastroenterol

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