Prof Zvi Zadik M.D.
Institute of Biochemistry, Food Science and Nutrition
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My research and teaching activities focus on the
metabolism, physiology and mechanism of growth and
nutrition, growth promoting medications and nutritional
modulation of hormonal system in children and
adolescents.
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Director, Pediatric Endocrine Unit,
Kaplan Medical Center
Institute of Biochemistry, Food Science and Nutrition,
The Robert H. Smith Faculty of Agriculture, Food and Environment
The Hebrew University of Jerusalem.
P.O. Box 12, Rehovot 76100, Israel.
Tel: 972-8-9489020.
E-mail address: zvizadik@012.net.il
Our main research interests are:
- Growth patterns of Israeli children. Cumulative data base
since 1977
- Nutritional effects on growth:
- Vitamins and trace elements.
- Interaction of vitamin A and iron.
- Effect of nutrition on puberty.
- Pediatric and maternal nutrition: Interaction of nutrition
and growth: in short children and IUGR.
- Effect of nutrition on response to growth promoting
medications.
- Growth hormone clinical trials
- Effect of growth, nutrition and physical activity on bone
mass accumulation
Selected Publications – from last five years
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Zadik Z, Frishberg Y , Drukker A , Blachar Y , Lotan D ,
Levi S, Reifen R 1998 Excessive dietary protein and suboptimal
caloric intake have a negative effect on the growth of children
with chronic renal disease before and during growth hormone
therapy. Metabolism. 47:264-268.
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Zadik Z , Amer R, Dolfin Z,, Arnon S , Cohen D ,
Mogilner B , Reifen Rc 1999 Urinary free cortisol (UFC) values
in newborns under stress. J Pediatr Endocrinol Metab.
12:543-547.
- Hochberg Z , Zadik Z 1999 Final height in young women
with Turner syndrome after GH therapy: an open controlled study.
Eur J Endocrinol. 141:218-24.
- Zung A , Phillip M, Chalew SA, Palese T, Kowarski AA,
Zadik Z 1999 Testosterone effect on growth and growth
mediators of the GH-IGF-I axis in the liver and epiphyseal growth
plate of juvenile rats. J Mol Endocrinol. 23:209-221
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Zadik Z, Chalew SA 1999 Short stature. Isr Med Assoc J.
1:206-208.
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Zadik Z, Wittenberg I, Segal N, Altman Y, Zung A, Gross
V , Reifen R 2001 Interrelationship between insulin, leptin and
growth hormone in growth hormone-treated children. Int J Obes
Relat Metab Disord. 25:538-542.
- Zung A, Reifen R, Kerem Z, Zadik Z 2001
Phytoestrogens: the pediatric perspective. J Pediatr
Gastroenterol Nutr. 33:112-118.
- Zung A, Zadik Z 2002. Continuous subcutaneous glucose
monitoring in children with type 1 diabetes. Pediatrics. 109:347.
- Hochberg Z, Bereket A, Davenport M, Delemarre-Van de Waal HA,
De Schepper J, Levine MA, Shaw N, Schoenau E, van Coeverden SC,
Weisman Y, Zadik Z, 2002 European Society for Paediatric
Endocrinology (ESPE) Bone Club. Consensus development for the
supplementation of vitamin D in childhood and adolescence. Horm
Res. 58:39-51
- Aimaretti G, Baffoni C ,Di Vito L, Grottoli S , Gaia D, Gasco
V, Giordano R, Zadik Z, Camanni F , Ghigo E, Arvat E 2003
Hypopituitaric patients with corticotropin insufficiency show
marked impairment of the cortisol response to ACTH (1-24)
independently of the duration of the disease. J Endocrinol
Invest. 26:49-55.
- Blank S, Zadik Z , Katz I, Mahazri Y ,Toker I, Barak
I. 2002 The emergence and treatment of anorexia and bulimia
nervosa. A comprehensive and practical model. Int J Adolesc Med
Health. 14:257-260.
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Zadik Z. 2003 Physiological but not pharmacological
growth hormone tests predict adult height. Clin Endocrinol
(Oxf). 59:25-26.
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Zadik Z, Price D, Diamond G. 2003 Pediatric reference
curves for multi-site quantitative ultrasound and its
modulators. Osteoporos Int. 14:857-862
- Zung A, Zadik Z. 2003 Acarbose treatment of infant
dumping syndrome: extensive study of glucose dynamics and
long-term follow-up. J Pediatr Endocrinol Metab. 16 :907-915.
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Zadik Z, Borondukov E, Zung A, Reifen R. 2003 Adult
height and weight of breast-fed and bottle-fed Israeli infants.
J Pediatr Gastroenterol Nutr 37:462-467.
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Zadik Z. 2003 Maternal nutrition, fetal weight, body
composition and disease in later life. J Endocrinol Invest.
26:941-945.
- Schoenau E, Saggese G, Peter F, Baroncelli GI, Shaw NJ,
Crabtree NJ, Zadik Z, Neu CM, Noordam C, Radetti G,
Hochberg Z. 2004 From Bone Biology to Bone Analysis. Horm Res.
2004; 61:257-69.
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Zadik Z 2004 Vitamin A and Iron are as effective as
hormonal therapy in delayed puberty Clin Endocrinol (Oxf).
60:682-7.
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Zadik Z 2004 Small for gestational age: Towards 2004 J
Endocrinol Invest. 26:1143-50.
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Zadik Z, Zung A, Reifen R. (2005) Longitudinal
monitoring of bone development measured by quantitative
multi-site ultrasound of bones in patients with crohns’
disease. J. Clin Gastroenterol 39:120-123
- Zung A, Glaser B , Nimri R , Zadik Z : (2004)
Glibenclamide treatment in permanent neonatal diabetes mellitus
due to an activating mutation in Kir6.2. J Clin Endocrinol Metab.
89:5504-7.
- Zung A , Yaron A , Altman Y , Zadik Z :
(2005){beta}-Adrenergic Hyperresponsiveness in Compensated
Hypothyroidism Associated with Down Syndrome. Pediatr Res.
58:66-70
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Zadik Z, Sinai T , Zung A , Reifen R . (2005) Effect of
nutrition on growth in short stature before and during growth
hormone therapy Pediatrics 116:68-72
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Zadik Z, Zung A, Reifen R. Longitudinal monitoring of
bone development measured by quantitative multi-site ultrasound
of bones in patients with crohns’ disease. J. Clin
Gastroenterol
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