Breeding history, population structure and inheritance of complex traits
Species radiation and divergence involved the change in the genetic make-up as a result of both selection and stochastic processes. Hybridization of these diverged genomes within hybrids leads to novel phenotypes, including transgressive segregation and heterosis, in which the hybrids surpass its (homozygous) parents for growth and reproductive fitness. We study the interplay between genetic and phenotypic diversity in natural and in experimental plant and yeast populations. This includes integration of next generation sequencing and genomic data for studying the sources for genetic variation (in wild barley) and its association with complex phenotypes (initially in tomato and currently in sorghum and yeasts).
The way we identify causal genetic variation will serve breeders as a tool for marker assisted selections, and the results of these studies serve us for unraveling hitherto unknown mechanisms underlying cryptic variation found in plants. These observations also show us how breeding system has shaped heredity of those traits and their plasticity towards changing environments, thus providing new leads to associate genetic diversity with phenotypic stability against stress. These perhaps lost mechanisms which are still found in crop wild relatives (CWR) provide a good reason why it worth the trouble of performing field trials with these precious and wild populations.
- Hübner, S.*, Bdolach, E.*, Ein-Gedi, S., Korol, A., Schmid, K. and Fridman, E.(2013) Phenotypic Landscapes: phenological patterns in wild and cultivated barley. J Evol Biol 26(1):163-174 (*Equal contribution)
- Ben-Israel, I., Nida, H., Kilian, B., and Fridman, E. (2012) Heterotic trait locus (HTL) mapping identifies intra-locus interactions that underlie reproductive hybrid vigor in Sorghum bicolor . PLoS One 7(6):e38993.
- Hübner, S., Günther, T., Flavell, A., Graner, A., Fridman, E., Korol, A., and Schmid, K. (2012) Islands and streams: Clusters and gene flow in wild barley populations from the Levant. Mol Ecol 21:1115-1129.
- Yu, G., Nguyen, T.H., Guo, Y., Schauvinhold, I., Auldridge, M., Bhuiyan, N., Ben-Israel, I., Iijima, Y., Fridman, E., Noel, J.P., Pichersky, E.(2010) Enzymatic functions of wild tomato Solanum habrochaites glabratum methylketone synthases 1 and 2. Plant Phys154(1):67-77.
- Ben-Israel, I., Geng, Y., Adato, A., Auldrige, M., Nguyen, T., Schauvinhold, I., Aharoni, A., Noel, J., Pichersky, E., and Fridman, E.(2009) Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes. Plant Phys 151(4):1952-1964. (Cover paper)
- Hübner, S., Höffken, M., Oren, E., Haseneyer, G., Stein, N., Graner, A., Schmid, K., and Fridman, E.(2009) Strong correlation of wild barley (Hordeum spontaneum) population structure with temperature and precipitation variation. Mol Ecol18:1523-1536.
- Shemesh, K., Iijima, Y., and Fridman, E. (2008) Targeted and non-targeted mutagenesis of metabolic pathways in medicinal plants and herbs. Israel J Plant Sci55: 115-123.
- Koeduka, T.*, Fridman, E.*, Gang, D.R.*, Vassão, D.G., Jackson, B.L., Kish, C.M., Orlova, I., , Spassova, S.M., Lewis, N.G., Noel, J.P., Baiga, T.J. , Dudareva, N., Pichersky, E. (2006) Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. Proc Natl Acad Sci USA103: 10128-10133. (* Equal contribution; cover paper)
- Fridman, E., Wang, J., Iijima, Y., Froehlich, J.E., Gang, D.R., Ohlrogge, J. and Pichersky, E.(2005) Metabolic, genomic and biochemical analyses of glandular trichome from the wild tomato species Lycopersicon hirsutum identify a key enzyme in the methylketone biosynthetic pathway. Plant Cell17: 1252-1267.
- Fridman, E. and Pichersky, E. (2005) Metabolomics, proteomics, genomics and identification of enzymes substrates. Curr Opin Plant Bio8: 242-248.
- Forouhar, F., Yang, Y., Kumar, D., Chen, Y. ,Fridman, E., Wook, P.S.,Chiang, Y., Acton, T.B., Montelione, G.T., Pichersky, E., Klessig, D.F. and Liang, T.L. (2005) Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity. Proc Natl Acad Sci USA102: 1773-1778.
- Iijima, Y., Gang, D.R., Fridman, E., Lewinsohn, E. and Pichersky, E. (2004) Characterization of geraniol synthase from the peltate glands of sweet basil. Plant Phys.134: 370-379.
- Iijima,Y., Davidovich-Rikanati, R., Fridman, E., Gang, D.R., Bar, E., Lewinsohn, E. and Pichersky, E. (2004) The biochemical and molecular basis for the divergent patterns in the biosynthesis of terpenes and phenylpropenes in the peltate glands of three cultivars of basil (Ocimum basilicum) . Plant Phys.136: 3724-3736.
- Fridman, E.*, Carrari, F.*, Liu, Y.S., Fernie, A. and Zamir, D. (2004) Zooming-in on a quantitative trait for tomato yield using wild species introgression lines. Science305: 1786-1789. (*Equal contribution)
- Fridman, E. and Zamir, D. (2003) Functional divergence of a syntenic invertase gene family in tomato, potato and Arabidopsis. Plant Phys.131: 603-609.
- Fridman, E., Liu, Y.S., Carmel-Goren, L., Gur, A., Shoresh, M., Pleban, T., Eshed, Y. and Zamir, D.(2002) Two tightly linked QTLs modify tomato sugar content via distinct physiological pathways. Mol. Genet. Genomics266: 821-826.
- Monforte, A.J., Fridman, E., Zamir, D. and Tanksley, S.D. (2001) Comparison of a set of allelic QTL-NILs for chromosome 4 of tomato: Deductions about natural variation and implications for germplasm utilization. Theor. Appl. Genet.102: 572-590.
- Fridman, E., Pleban, T. and Zamir, D. (2000) A recombination hotspot delimits a wild species QTL for tomato sugar content to 484-bp within an invertase gene. Proc. Natl. Acad. Sci. USA97: 4718-4723.
- Fulton, T.M., Grandillo, S., Beck-Bunn, T., Fridman, E., Frampton, A., Lopez, J., Petiard, V., Uhlig, J. ,Zamir, D. and Tanksley, S.D. (2000) Advanced backcross analysis of Lycopersicon esculentum x L. parviflorum cross. Theor. Appl. Genet.100: 1025-1042.